Semaglutide Reconstitution Calculator
Prescription medication — use only as prescribed by a licensed clinician.
Semaglutide is a GLP-1 receptor agonist and a prescription medication (branded Ozempic, Wegovy, and Rybelsus). Any semaglutide you use should be prescribed and supervised by a licensed clinician; the calculator here is only for converting a prescribed dose into a draw volume when using a vial that must be reconstituted.
Enter the milligrams on your vial, the bacteriostatic water added, and the dose your prescriber specified. The tool returns the exact mL to draw and the tick on a U-100 insulin syringe (1 IU = 0.01 mL). Semaglutide doses are small, so concentration matters — a small water volume keeps the draw on a readable mark.
The dosage chart mirrors the standard label titration schedule (0.25 mg → 2.4 mg) to illustrate how each step maps to a draw. It is educational arithmetic, not a recommendation — follow the exact dose your clinician prescribed.
Tip: adding 2 mL of bacteriostatic water would put this dose on a clean, easy-to-read mark on a U-100 insulin syringe.
Educational math only — not medical advice, and not a dose recommendation. The dose above is the value you entered. Always follow a licensed clinician’s instructions. Investigational compounds are not FDA-approved.
Semaglutide Dosage Chart
Commonly-cited dose points (label titration range, 0.25–2.4 mg) at a 5 mg vial reconstituted with 2 mL of bacteriostatic water. The volume and syringe columns are computed from those inputs — illustrative math, never a dose recommendation.
| Example dose | Volume to draw | U-100 syringe | Notes |
|---|---|---|---|
| 0.25 mg (250 mcg) | 0.100 mL | 10 IU | typical titration start |
| 0.5 mg (500 mcg) | 0.200 mL | 20 IU | — |
| 1 mg (1,000 mcg) | 0.400 mL | 40 IU | — |
| 1.7 mg (1,700 mcg) | 0.680 mL | 68 IU | — |
| 2.4 mg (2,400 mcg) | 0.960 mL | 96 IU | label maximum |
How to use this calculator
- Vial size — the milligrams printed on your Semaglutide vial (commonly 5 or 2 or 10 mg).
- Bacteriostatic water — how much you add to dissolve the powder. More water = a larger, easier-to-read draw at the same dose.
- Dose — the amount you intend to draw, in micrograms. This is your number, not a recommendation.
- Read the IU mark — on a U-100 insulin syringe, 1 IU = 0.01 mL. The calculator shows the exact tick to fill to.
Semaglutide FAQ
- How do I reconstitute compounded semaglutide?
- Add the bacteriostatic water specified by your pharmacy or prescriber slowly into the vial and swirl gently. Use the calculator above to convert your prescribed dose and the resulting concentration into the exact U-100 insulin-syringe units to draw.
- How many units is 0.25 mg of semaglutide?
- It depends on concentration. A 5 mg vial reconstituted with 2 mL yields 2,500 mcg/mL, so a 250 mcg (0.25 mg) dose is 0.1 mL, which is 10 IU on a U-100 insulin syringe. Change the vial size or water volume to match your own prescription.
- Is semaglutide a prescription medication?
- Yes. Semaglutide is FDA-approved and prescription-only. This page is a math tool for a dose your clinician has already prescribed; it does not recommend a dose and is not medical advice.
- How is reconstituted semaglutide stored?
- Reconstituted semaglutide is generally refrigerated and used within the timeframe your pharmacy specifies. Always follow the storage and beyond-use guidance provided with your prescription.