PT-141 Dosage Calculator
PT-141 (bremelanotide) is a melanocortin-receptor agonist. Its acetate salt is FDA-approved as Vyleesi for a specific indication at a fixed 1.75 mg subcutaneous dose; research-grade lyophilized PT-141 sold for laboratory use is investigational and not FDA-approved.
The calculator below is a pure math tool: enter the milligrams printed on your vial, the bacteriostatic water you are adding, and the dose you intend to draw. It returns the exact volume in millilitres and the corresponding tick on a U-100 insulin syringe, where 1 IU = 0.01 mL.
The PT-141 dosage chart shows how commonly-referenced dose points translate to a draw at your chosen vial size and water volume. Every figure is illustrative arithmetic, not a recommendation — your clinician sets any dose, frequency, and route.
Tip: adding 1 mL of bacteriostatic water would put this dose on a clean, easy-to-read mark on a U-100 insulin syringe.
Educational math only — not medical advice, and not a dose recommendation. The dose above is the value you entered. Always follow a licensed clinician’s instructions. Investigational compounds are not FDA-approved.
PT-141 Dosage Chart
Commonly-cited dose points (commonly-cited research range) at a 10 mg vial reconstituted with 2 mL of bacteriostatic water. The volume and syringe columns are computed from those inputs — illustrative math, never a dose recommendation.
| Example dose | Volume to draw | U-100 syringe | Notes |
|---|---|---|---|
| 0.5 mg (500 mcg) | 0.100 mL | 10 IU | — |
| 1 mg (1,000 mcg) | 0.200 mL | 20 IU | — |
| 1.5 mg (1,500 mcg) | 0.300 mL | 30 IU | — |
| 1.75 mg (1,750 mcg) | 0.350 mL | 35 IU | the Vyleesi label single dose |
| 2 mg (2,000 mcg) | 0.400 mL | 40 IU | — |
How to use this calculator
- Vial size — the milligrams printed on your PT-141 vial (commonly 10 or 5 mg).
- Bacteriostatic water — how much you add to dissolve the powder. More water = a larger, easier-to-read draw at the same dose.
- Dose — the amount you intend to draw, in micrograms. This is your number, not a recommendation.
- Read the IU mark — on a U-100 insulin syringe, 1 IU = 0.01 mL. The calculator shows the exact tick to fill to.
PT-141 FAQ
- How do I reconstitute a PT-141 vial?
- Add bacteriostatic water slowly down the inside wall of the vial, let the powder dissolve without shaking, and store it refrigerated. The exact water volume determines your concentration; use the calculator above to see the resulting mcg/mL and the mark to draw on a U-100 insulin syringe.
- How many units is a PT-141 dose on an insulin syringe?
- On a U-100 insulin syringe every 1 IU tick equals 0.01 mL. The calculator converts your dose and concentration into the exact number of units to fill to — for example, a 10 mg vial reconstituted with 2 mL yields 5,000 mcg/mL, so a 1,000 mcg draw is 0.2 mL, or 20 IU.
- Is the PT-141 dosage chart a recommendation?
- No. The chart lists commonly-cited research and label figures purely to illustrate the reconstitution math. It is educational, not medical advice, and it is not a dose recommendation. Always follow a licensed clinician.
- How should reconstituted PT-141 be stored?
- Once mixed, peptides are generally kept refrigerated (about 2–8 °C) and protected from light, and the unmixed powder is kept in a freezer. Follow the storage guidance provided with your specific product and by your clinician.